Publications

See the complete list of Dr. Dutta’s published work

Selected Publications:

• Zhang X, Ohayon-Steckel L, Coppin E, Johny E, Dasari A, Florentin J, Vasamsetti S, Dutta P. Epidermal Growth Factor Receptor in Hepatic Endothelial Cells Suppresses MCP-1-Dependent Monocyte Recruitment in Diabetes. J Immunol. 2023 Mar 22;. doi: 10.4049/jimmunol.2200557. [Epub ahead of print] PubMed PMID: 36946774; NIHMSID:NIHMS1880380.

• Coppin E, Zhang X, Ohayon L, Johny E, Dasari A, Zheng KH, Stiekema L, Cifuentes-Pagano E, Pagano PJ, Chaparala S, Stroes ES, Dutta P. Peripheral Ischemia Imprints Epigenetic Changes in Hematopoietic Stem Cells to Propagate Inflammation and Atherosclerosis. Arterioscler Thromb Vasc Biol. 2023 Mar 9;. doi: 10.1161/ATVBAHA.123.318956. [Epub ahead of print] PubMed PMID: 36891902; NIHMSID:NIHMS1877236.
  • ATVB “Editor’s Pick” – June 2023
  • Emanueli C, Schmidt AM, Golledge J. Unveiling Intriguing Links Between Limb Ischemia, Systemic Inflammation, and Progressive Atherosclerosis: A Tangled and Interconnected Web. Arterioscler Thromb Vasc Biol. 2023 Jun;43(6):907-909. doi: 10.1161/ATVBAHA.123.319191. Epub 2023 Apr 13. PMID: 37051930.

• Florentin J, Zhao J, Tai YY, Sun W, Ohayon LL, O’Neil SP, Arunkumar A, Zhang X, Zhu J, Al Aaraj Y, Watson A, Sembrat J, Rojas M, Chan SY, Dutta P. Loss of Amphiregulin drives inflammation and endothelial apoptosis in pulmonary hypertension. Life Sci Alliance. 2022 Jun 22;5(11):e202101264. doi: 10.26508/lsa.202101264. PMID: 35732465.

• Florentin J, O’Neil SP, Ohayon LL, Uddin A, Vasamsetti SB, Arunkumar A, Ghosh S, Boatz JC, Sui J, Kliment CR, Chan SY, Dutta P. VEGF receptor 1 promotes hypoxia-induced hematopoietic progenitor proliferation and differentiation. Frontiers in Immunology. 2022.

• Florentin J, Zhao J, Tai YY, Vasamsetti SB, O’Neil SP, Kumar R, Arunkumar A, Watson A, Sembrat J, Bullock GC, Sanders L, Kassa B, Rojas M, Graham BB, Chan SY, Dutta P. Interleukin-6 mediates neutrophil mobilization from bone marrow in pulmonary hypertension. Cell Mol Immunol. 2021 Jan 8. doi: 10.1038/s41423-020-00608-1. Epub ahead of print. PMID: 33420357.

• Vasamsetti SB, Coppin E, Zhang X, Florentin J, Koul S, Gotberg M, Clugston AS, Thoma F, Sembrat J, Bullock GC, Kostka D, St. Croix CM, Chattopadhyay A, Rojas M, Mulukutla S, Dutta P. Apoptosis of hematopoietic progenitor-derived adipose tissue resident macrophages contributes to insulin resistance after myocardial infarction. Sci Trans Med, 2020

• Zhao J, Florentin J, Tai Y, Torrino S, Ohayon L, Brzoska T, Tang T, Negi V, Woodcock CC, Risbano M, Nouraje SM, Sundd P, Bertero T*, Dutta P*, Chan SY*. Long range endocrine delivery of circulating miR-210 to endothelium promotes pulmonary hypertension. Circ Res. 2020. *Co-senior authors.

• Hoyer FF+, Zhang X+, Coppin E, Vasamsetti SB, Modugu G, Schloss M, McAlpine CS, Iwamoto Y, Libby P, Naxerova K, Swirski FK, Dutta P*, Nahrendorf M*. Bone marrow endothelial cells regulate myelopoiesis in diabetes. Circulation. 2020. Accepted for publication. +Co-first authors. *Co-senior authors and Co-corresponding authors.

• Vasamsetti SB, Florentin J, Coppin E, Stiekema L, Zheng KH, Nisar MU, Levinthal D, Rojas M, Stroes ES, Kim K, Dutta P. Sympathetic neuronal activation triggers myeloid progenitor proliferation and differentiation. Immunity. 2018. pii: S1074-7613(18)30240-1. doi: 10.1016/j.immuni.2018.05.004.  PMID: 29958804.

• Florentin J, Coppin E, Vasamsetti SB, Zhao J, Tai YY, Tang Y, Zhang Y, Watson A, Sembrat J, Rojas M, Vargas SO, Chan SY*, Dutta P*. Inflammatory macrophage expansion in pulmonary hypertension depends upon mobilization of blood-borne monocytes. J of Immunol. 2018. (Epub ahead of print). PMID: 29632145. *Co-senior authors.

• Coppin E, Florentin J, Vasamsetti SB, Arunkumar A, Sembrat J, Rojas M, Dutta P. Splenic hematopoietic stem cells display a pre-activated phenotype. Immunol Cell Biol. 2018 (Epub ahead of print). IMID: 29526053

• Dutta P, Hoyer FF, Sun Y, Iwamoto Y, Tricot B, Weissleder R, Magnani JL, Swirski FK, Nahrendorf M. E-selectin inhibition mitigates splenic HSC activation and myelopoiesis in hypercholesterolemic mice with myocardial infarction. Atheroscler Thromb Vasc Biol 2016 Sep;36(9):1802-8. PMCID: PMC5001901

• Bracamonte-Baran W, Florentin J, Zhou Y, Jankowska-Gan E, Haynes WJ, Zhong W, Brennan TV, Dutta P, Class FH, va Rood JJ, Burlingham WJ. Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance. Proc Natl Acad Sci Jan 31;114(5):1099-1104. PMCID: PMC5293109

• Sager HB*, Dutta P*, Dahlman JE, Borodovsky A, Fitzgerald K, Heidt T, Courties G, Wojtkiewicz GR, Iwamoto Y, Sebas M, Khan OF, Xing Y, Shaw TE, Libby P, Swirski FK, Langer R, Weissleder R, Anderson DG, Nahrendorf RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction. Sci Transl Med. 2016 Jun 8;8(342):342ra80 PMID: 27280687. *Equal contribution

• Dutta P, Sager H, Stengel K, Naxerova K,……Libby P, Hiebert S, Scadden D, Swirski FK, Weissleder R, Nahrendorf M. 2015. Myocardial infarction activates CCR2⁺ hematopoietic stem cells. Cell Stem Cell 16: 477-87.
  Correspondence: Partha Dutta (dutta.partha@mgh.harvard.edu) and Matthias Nahrendorf (mnahrendorf@mgh.harvard.edu)

• Dutta, P., F. F. Hoyer, L. S. Grigoryeva, H. B. Sager, F. Leuschner, G. Courties, A. Borodovsky, T. Novobrantseva, V. M. Ruda, K. Fitzgerald, Y. Iwamoto, G. Wojtkiewicz, Y. Sun, N. Da Silva, P. Libby, D. G. Anderson, F. K. Swirski, R. Weissleder, and M. Nahrendorf. 2015. Macrophages retain hematopoietic stem cells in the spleen via VCAM-1 in atherosclerosis. Journal of Experimental Medicine 212: 497-512.
  Correspondence: Partha Dutta (dutta.partha@mgh.harvard.edu) and Matthias Nahrendorf (mnahrendorf@mgh.harvard.edu)

• Sager HB, T. Heidt, M. Hulsmans, Dutta, G. Courties, M. Sebas, G. R. Wojtkiesicz, B. Tricot, Y. Iwamoto, Y. Sun, R. Weissleder, P. Libby, F.K. Swirski, M. Nahrendorf. 2015. Targeting interleukin-1beta reduces leukocyte production after acute myocardial infarction. Circulation.

• Dutta, P., G. Courties, Y. Wei, F. Leuschner, R. Gorbatov, C. S. Robbins, Y. Iwamoto, B. Thompson, A. L. Carlson, T. Heidt, M. D. Majmudar, F. Lasitschka, M. Etzrodt, P. Waterman, M. T. Waring, A. T. Chicoine, A. M. van der Laan, H. W. Niessen, J. J. Piek, B. B. Rubin, J. Butany, J. R. Stone, H. A. Katus, S. A. Murphy, D. A. Morrow, M. S. Sabatine, C. Vinegoni, M. A. Moskowitz, M. J. Pittet, P. Libby, C. P. Lin, F. K. Swirski, R. Weissleder, and M. Nahrendorf. 2012. Myocardial infarction accelerates atherosclerosis. Nature 487: 325-329.

• Heidt, T., H. B. Sager, G. Courties, Dutta, Y. Iwamoto, A. Zaltsman, C. von Zur Muhlen, C. Bode, G. L. Fricchione, J. Denninger, C. P. Lin, C. Vinegoni, P. Libby, F. K. Swirski, R. Weissleder, and M. Nahrendorf. 2014. Chronic variable stress activates hematopoietic stem cells. Nature Medicine 20: 754-758.

• Leuschner, F*., Dutta*, R. Gorbatov, T. I. Novobrantseva, J. S. Donahoe, G. Courties, K. M. Lee, J. I. Kim, J. F. Markmann, B. Marinelli, P. Panizzi, W. W. Lee, Y. Iwamoto, S. Milstein, H. Epstein-Barash, W. Cantley, J. Wong, V. Cortez-Retamozo, A. Newton, K. Love, P. Libby, M. J. Pittet, F. K. Swirski, V. Koteliansky, R. Langer, R. Weissleder, D. G. Anderson, and M. Nahrendorf. 2011. Therapeutic siRNA silencing in inflammatory monocytes in mice. Nature Biotechnology 29: 1005-1010. * Equal contribution authors

• Dutta, P., M. Dart, D. A. Roenneburg, J. R. Torrealba, and W. J. Burlingham. 2011. Pretransplant immune-regulation predicts allograft tolerance. Am J Transplant 11: 1296-1301.

• Dutta, P., M. Molitor-Dart, J. L. Bobadilla, D. A. Roenneburg, Z. Yan, J. R. Torrealba, and W. J. Burlingham. 2009. Microchimerism is strongly correlated with tolerance to noninherited maternal antigens in mice. Blood 114: 3578-3587.