People

Principal Investigator

Partha Dutta, DVM, PhD

Partha Dutta, DVM, PhD

Assistant Professor of Medicine, Division of Cardiology

Phone:  412-383-7787
Email:  duttapa@pitt.edu

 

Education

DVM, West Bengal University of Animal and Fishery Sciences, India, 2003
MS, Wichita State University, KS, 2006
PhD, University of Wisconsin-Madison, WI, 2010

Training

Postdoctoral Training, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 2013
Instructor, Harvard Medical School, 2015

Postdocs and Fellows

Jonathan Florentin, PhD

Postdoctoral Associate

1720 BST
200 Lothrop Street
Pittsburgh, PA 15261

Lab Phone: 412- 648-8469
Email: jflor@pitt.edu

Dr. Florentin received his master’s degree in Human Pathology and Infectious Diseases in 2009 from the Faculty of Medicine Aix-Marseille University, France. He was awarded with the French Ministry of Research and Technology fellowship in 2009 to study the impact of Hepatitis C Virus (HCV) on a subset of cells of the innate immunity, the plasmacytoid dendritic cells (pDCs) in Dr. Ivan HIrsch lab at CRCM-INSERM (France). In 2013, he obtained his PhD in Human Pathology and Immunology from Aix-Marseille University, France. In 2013, he joined Michael Gale Jr. lab in Seattle, WA, USA, to study the relevance of dendritic cells in the context of West Nile Virus (WNV) and Dengue Virus infections (DenV). In 2015, he joined Dr. William Burlingham’s lab at the University of Wisconsin-Madison, WI, USA to investigate the role of maternal microchimerism derived exosomes in antigen acquisition in the context of transplantation. He then joined Dr. Partha Dutta’s lab in the Vascular Medicine Institute at the University of Pittsburgh, PA, USA, to work on change in hematopoietic stem and progenitor cells and function of inflammatory cells in pulmonary hypertension.

Publications

Zona L, Lupberger J, Sidahmed-Adrar N, Thumann C, Harris HJ, Barnes A, Florentin J, Tawar RG, Xiao F, Turek M, Durand SC, Duong FH, Heim MH, Cosset FL, Hirsch I, Samuel D, Brino L, Zeisel MB, Le Naour F, McKeating JA, Baumert TF. HRas signal transduction promotes hepatitis C virus cell entry by triggering assembly of the host tetraspanin receptor complex. Cell Host Microbe. 2013 Mar 13;13(3):302-13.

Florentin, J., Aouar, B., Dental, C., Thumann, C., Firaguay, G., Gondois-Rey, F., Soumelis,V., F. Baumert, T., A. Nunès, J., Olive, D., Hirsch, I., Stranska, R.* HCV glycoprotein E2 is a novel BDCA-2 ligand and acts as an inhibitor of IFN production by plasmacytoid dendritic cells. Blood 2012 Nov 29;120(23):4544-51.

Dental,C., Florentin, J., Aouar, B., Gondois-Rey, F., Durantel, D., Baumert, T. F., Nunes, J. A., Olive, D., Hirsch, I., and Stranska, R. Hepatitis C virus fails to activate NF-kappaB signaling in plasmacytoid dendritic cells. J Virol. 2012;86:1090-1096.

Sathish Vasamsetti, PhD

Postdoctoral Associate

1720 BST
200 Lothrop Street
Pittsburgh, PA 15261

Phone: 412-624-4059
Email: sathishv@pitt.edu

Dr. Vasamsetti received his masters degree in microbiology in 2008 from Acharya Nagarjuna University, India. He was awarded with CSIR junior research fellowship in 2009 to study the mechanisms of monocyte to macrophage differentiation along with the identification of key cellular targets during this process in cardiovascular disorders in Dr. Kotamraju S lab at CSIR-IICT (India).  In 2015, he was awarded with PhD in Biochemistry from Academic Council of Scientific and Industrial Research (AcSIR), India. In 2016, he joined Dr. Partha Dutta’s lab to investigate the differential regulation of tissue resident and monocyte-derived macrophages in myocardial infarction-induced insulin resistance in the Vascular Medicine Institute at the University of Pittsburgh.

Publications

Vasamsetti SB, Karnewar S, Kanugula AK, Kotamraju S.  Metformin inhibits monocyte-to-macrophage differentiation via AMPK mediated inhibition of STAT3 activation: Potential role in atherosclerosisDiabetes 2015; 64:2042-2055.

Gannarapu MR, Vasamsetti SB, Punna N, Kotamraju S, Banda N. Design and synthesis of novel 1-substituted-triazole linked 1,2-benzothiazine 1,1-dioxido propenone derivatives and their evaluation as potent anti-inflammatory agents and inhibitors of monocyte-to-macrophage transformation.  Med Chem Comm 2015:6:1494-1500.

Kanugula AK, Gollavilli PN, Vasamsetti SB, Karnewar S, Gopoju R, Ummanni R, Kotamraju S. Statin-induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: Intermediacy of nitric oxide and antioxidant defence mechanisms. FEBS J. Aug;281(16):3719-38.

Sambasiva Rao P, Kurumurthy C, Veeraswamy B, Santhosh Kumar G, Poornachandra Y, Ganesh Kumar C, Vasamsetti SB, Kotamraju S, Narsaiah B. Synthesis of novel 1,2,3-triazole substituted-N-alkyl/aryl nitrone derivatives, their anti-inflammatory and anticancer activity. Eur J Med Chem. 2014 Jun 10; 80:184-91.

Gannarapu MR, Vasamsetti SB, Punna N, Royya NK, Pamulaparthy SR, Nanubolu JB, Kotamraju S, Banda N. Synthesis of novel 1,2-benzothiazine 1,1-dioxide-3-ethanone oxime N-aryl acetamide ether derivatives as potent anti-inflammatory agents and inhibitors of monocyte-to-macrophage transformation. Eur J Med Chem.2014 Mar 21;75:143-50.

Koppireddi S, Komsani JR, Avula S, Pombala S, Vasamsetti S, Kotamraju S, Yadla R. Novel 2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamides as antioxidant and/or anti-inflammatory compounds. Eur J Med Chem. 2013 Aug; 66:305-13.

Graduate Students

Deba Imafidon

Graduate Student
Biomedical Master’s Program

dee22@pitt.edu

Scott O’Neil

Medical Student

O’Neil.Scott@medstudent.pitt.edu

Scott O’Neil received his bachelor’s degree in Biology in 2016 from St. Lawrence University. During his undergraduate studies he was awarded two research internship opportunities at Pfizer Pharmaceuticals to study immune tolerance as a member of a rare disease team. He continued to conduct research regarding the role of innate immune cells in auto inflammatory conditions and mechanisms of immune tolerance with Dr. Joseph Erlichman’s lab at St. Lawrence University. In 2016 he matriculated into the medical school at the University of Pittsburgh and later joined Dr. Partha Dutta’s lab in the Vascular Medicine Institute where he is studying mechanisms of atherosclerosis and the role of innate immune cells.

Xinyi is a visiting scholar from Xiangya School of Medicine, P. R. China. She is a medical student of eight-year program, which means it will take eight years to get the M.D. In 2017, she participated in the Xiangya-University of Pittsburgh Research Program, and then joined Dr. Partha Dutta’s lab in the Vascular Medicine Institute at the University of Pittsburgh, PA, USA, to investigate the pathogenesis of macrophage in cardiovascular diseases.

Undergraduate Students

Anagha Arunkumar

Undergraduate Student Researcher

ana115@pitt.edu

Anagha is an undergraduate student at the University of Pittsburgh majoring in Neuroscience and minoring in Chemistry and Gender studies. Anagha became part of the Dutta lab in the summer of 2017 and works on genotyping mice and working with post-docs in their experiments.

Aleef Mannan

Undergraduate Student Researcher

aam141@pitt.edu

Aleef Mannan graduated from State College Area High School in 2017, and is currently an undergraduate student at the University of Pittsburgh. Aleef is a pre-medical student majoring in Biological Sciences and minoring in Chemistry, with a Certificate in Conceptual Foundations of Medicine. Aleef joined Dr. Partha Dutta’s lab in the fall of 2018, and works on the role of ATP-citrate lyase in atherosclerosis.

Ganesh Modugu

Undergraduate Student Researcher

grm47@pitt.edu

Ganesh Modugu graduated from South Brunswick High School in 2017 and began schooling at the University of Pittsburgh in 2021. As an aspiring pre-medical student, Ganesh is a neuroscience major candidate in the Dietrich School of Arts and Sciences. Ganesh joined Dr. Dutta’s lab in the fall of 2017, and works on the role of RBPJ, a transcriptional repressor protein, in atherosclerosis.