Dutta lab has found that myocardial infarction generates de novo insulin resistance in patients and mice.
It is well accepted that insulin resistance precipitates myocardial infarction. In a retrospective study, we found that only 24% of patients are diabetic at the time of ST elevation myocardial infarction (STEMI). However, within a month after STEMI, most patients exhibited hyperglycemia, indicating that a significant number of patients develop insulin resistance after STEMI. Encouraged by this finding, we performed a retrospective analysis, which revealed that 50% of the patients who are normoglycemic before STEMI develop fasting hyperglycemia.
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