Dutta lab, in collaboration with Nahrendorf lab at Harvard Medical School, has shown in a recent issue of Circulation that epidermal growth factor receptor is important in suppressing myelopoiesis in diabetes. In absence of this receptor, hematopoietic stem and progenitor cells proliferate vigorously and differentiate into inflammatory myeloid cells.


Hoyer FF, Zhang X, Coppin E, Vasamsetti SB, Modugu G, Schloss MJ, Rohde D, McAlpine CS, Iwamoto Y, Libby P, Naxerova K, Swirski FK, Dutta P, Nahrendorf M. Bone Marrow Endothelial Cells Regulate Myelopoiesis in Diabetes. Circulation. 2020 Apr 22. doi: 10.1161/CIRCULATIONAHA.120.046038. Epub ahead of print. PMID: 32316750.